Recombinant Angiopoietin 2 抗体
Quick Overview for Recombinant Angiopoietin 2 抗体 (ABIN5564224)
抗原
See all Angiopoietin 2 (ANGPT2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes human and mouse angiopoietin-2.
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交叉反应
- 人, 小鼠
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交叉反应 （详细）
- Does not detect human angiopoietin-1.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human angiopoietin-2.
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亚型
- IgG2b
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anti-Angiopoietin 2 (ANGPT2) (AA 24-165) antibody
ANGPT2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 19-147) antibodyANGPT2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) antibodyANGPT2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 404-432), (C-Term) antibodyANGPT2 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB17789 unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 401-496) antibodyANGPT2 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 19-483) antibodyANGPT2 适用: 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 19-485) antibodyANGPT2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (N-Term) antibodyANGPT2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (N-Term) antibodyANGPT2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 2 (ANGPT2) (AA 19-348) antibodyANGPT2 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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说明
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anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) (preservative free) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol.
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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- Angiopoietin 2 (ANGPT2)
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别名
- Angiopoietin-2
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背景
- Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. anti-Angiopoietin-2, mAb (rec.) (blocking) (Angy-2-1) (preservative free) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
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UniProt
- O15123
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途径
- RTK signaling
抗原
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