CDK6 抗体
Quick Overview for CDK6 抗体 (ABIN5557433)
抗原
See all CDK6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant human Cdk6 protein, full length.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 3-99) antibody
CDK6 适用: 人 WB, IF, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 8H4 unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) antibodyKO Validated CDK6 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 280-325) antibodyCDK6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) antibodyCDK6 适用: 人, 大鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 8H4 unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 21-110) antibodyCDK6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) (pTyr24) antibodyCDK6 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) (N-Term) antibodyCDK6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 102-326) antibodyCDK6 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 6 (CDK6) antibodyCDK6 适用: 人 WB, ELISA, IP 宿主: 兔 Monoclonal 8G3 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 1-326) antibodyCDK6 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
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别名
- Cdk6
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背景
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Synonyms: MCPH12, PLSTIRE, Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6
Background: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
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基因ID
- 1021
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UniProt
- Q00534
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
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