TIMD4 抗体 (AA 1-288)
Quick Overview for TIMD4 抗体 (AA 1-288) (ABIN5541407)
抗原
See all TIMD4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-288
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特异性
- Clone RMT4-54 specifically recognises mouse Tim-4. Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1 + cells), but not PEMs (peritoneal exudate Mac1 cells) [Nakayama, 2009]. Species: Mouse.
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纯化方法
- Affinity chromatography on Protein G
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免疫原
- Mouse TIMD4 (amino acids 1-288), coupled with the Fc portion of mouse IgG2a
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亚型
- IgG2a
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anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 134-301) antibody
TIMD4 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 333-361), (C-Term) antibodyTIMD4 适用: 人 WB 宿主: 兔 Polyclonal RB40431 unconjugated
anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (C-Term) antibodyTIMD4 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-130) antibodyTIMD4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (Center) antibodyTIMD4 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) antibodyTIMD4 适用: 小鼠 ELISA, FACS, IP, in vivo 宿主: 兔 Chimeric 5G3 unconjugated Recombinant Antibody
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应用备注
- Flow cytometry: 1/25-1/200, use 10 μL of this suggested working dilution to label 10e6 cells in 100 μL. Immunofluorescence. Immunohistochemistry on Paraffin sections. Positive control: Mouse spleen. For functional assays Cat.-No. AM60019LE-N is recommended.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.09 % Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
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别名
- timd4
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背景
- TIMD4 / TIM-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of TIM-1, involved in T-cell expansion and cytokine production. TIMD4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between TIM-1 on Th2 cells and TIM-4 on DCs, enhances Th2 cell function. The TIMD4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma.
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UniProt
- Q6U7R4
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途径
- Cancer Immune Checkpoints
抗原
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