CCR4 抗体
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北京 101111
Quick Overview for CCR4 抗体 (ABIN5541087)
抗原
See all CCR4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes Human CCR4. Other species not tested.
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纯化方法
- Affinity Chromatography on Protein G
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免疫原
- Immunisation with Human CCR4 peptide.
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亚型
- IgG2a
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应用备注
- Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 μg/10 6 cells. Immunofluorescence: 1 μg/10
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate buffered saline, pH 7.2
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
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别名
- cd194,ccr4
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背景
- CCR4 (CC chemokine receptor 4) belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane-bound molecules composed of 7-transmembrane domains and are coupled to G-proteins (1,2). CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells (3,4). It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways (2,5).
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UniProt
- P51679
抗原
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