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CCR4 抗体

This anti-CCR4 antibody is a 小鼠 单克隆 antibody detecting CCR4 in FACS, IF, ICC 和 EIA. Suitable for 人.
产品编号 ABIN5541087
发货至: 中国

Quick Overview for CCR4 抗体 (ABIN5541087)

抗原

See all CCR4 抗体
CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CCR4 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

克隆位点

KH-4F5
  • 特异性

    Recognizes Human CCR4. Other species not tested.

    纯化方法

    Affinity Chromatography on Protein G

    免疫原

    Immunisation with Human CCR4 peptide.

    亚型

    IgG2a
  • 应用备注

    Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 μg/10 6 cells. Immunofluorescence: 1 μg/10

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Phosphate buffered saline, pH 7.2

    储存条件

    4 °C,-20 °C

    储存方法

    Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

    有效期

    12 months
  • 抗原

    CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

    别名

    cd194,ccr4

    背景

    CCR4 (CC chemokine receptor 4) belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane-bound molecules composed of 7-transmembrane domains and are coupled to G-proteins (1,2). CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells (3,4). It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways (2,5).

    UniProt

    P51679
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