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Notch1 抗体 (Middle Region)

This anti-Notch1 antibody is a 兔 多克隆 antibody detecting Notch1 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN5518937
发货至: 中国

Quick Overview for Notch1 抗体 (Middle Region) (ABIN5518937)

抗原

See all Notch1 (NOTCH1) 抗体
Notch1 (NOTCH1) (Notch 1 (NOTCH1))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This Notch1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
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    AA 1797-1827, Middle Region

    原理

    Anti-Notch1 Antibody Picoband®

    序列

    LKNASDGALM DDNQNEWGDE DLETKKFRFE E

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-Notch1 Antibody Picoband® (ABIN5518937). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence in the middle region of human Notch1, identical to the related mouse and rat sequences.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Mouse, Human
    1. Conlon, R. A., Reaume, A. G., Rossant, J. : Notch1 is required for the coordinate segmentation of somites. Development 121: 1533-1545, 1995. 2. Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate". Neuron 29 (1): 45-55.

    说明

    We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    Notch1 (NOTCH1) (Notch 1 (NOTCH1))

    别名

    NOTCH1

    背景

    Synonyms: Neurogenic locus notch homolog protein 1,Notch 1,hN1,Translocation-associated notch protein TAN-1,Notch 1 extracellular truncation,NEXT,Notch 1 intracellular domain,NICD,NOTCH1,TAN1,

    Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

    Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1, DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

    分子量

    272 kDa

    基因ID

    4851

    UniProt

    P46531

    途径

    Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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