Notch1 抗体 (Middle Region)
Quick Overview for Notch1 抗体 (Middle Region) (ABIN5518937)
抗原
See all Notch1 (NOTCH1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1797-1827, Middle Region
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原理
- Anti-Notch1 Antibody Picoband®
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序列
- LKNASDGALM DDNQNEWGDE DLETKKFRFE E
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-Notch1 Antibody Picoband® (ABIN5518937). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Notch1, identical to the related mouse and rat sequences.
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Human
1. Conlon, R. A., Reaume, A. G., Rossant, J. : Notch1 is required for the coordinate segmentation of somites. Development 121: 1533-1545, 1995. 2. Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate". Neuron 29 (1): 45-55. -
说明
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We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
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别名
- NOTCH1
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背景
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Synonyms: Neurogenic locus notch homolog protein 1,Notch 1,hN1,Translocation-associated notch protein TAN-1,Notch 1 extracellular truncation,NEXT,Notch 1 intracellular domain,NICD,NOTCH1,TAN1,
Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1, DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
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分子量
- 272 kDa
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基因ID
- 4851
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UniProt
- P46531
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途径
- Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
抗原
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