C19ORF80 抗体 (AA 22-198)
Quick Overview for C19ORF80 抗体 (AA 22-198) (ABIN5518896)
抗原
See all C19ORF80 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-198
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原理
- Anti-C19orf80/ANGPTL8 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-C19orf80/ANGPTL8 Antibody Picoband® (ABIN5518896). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human C19orf80 recombinant protein (Position: A22-A198). Human C19orf80 shares 74% amino acid (aa) sequence identity with mouse C19orf80.
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亚型
- IgG
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anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibody
C19ORF80 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 16-198) antibodyC19ORF80 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 22-198) antibodyC19ORF80 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Monoclonal D3 unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 1-251) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Fu Z, Yao F, Abou-Samra AB, Zhang R (Jan 2013). "Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family". Biochemical and Biophysical Research Communications. 430 (3): 1126-31. 2. Yi P, Park JS, Melton DA (May 2013). "Betatrophin: a hormone that controls pancreatic β cell proliferation". Cell. 153 (4): 747-58. 3. Zhang R (Aug 2012). "Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels". Biochemical and Biophysical Research Communications. 424 (4): 786-92. -
说明
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We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))
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别名
- ANGPTL8
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背景
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Synonyms: Angiopoietin-like protein 8 ,Betatrophin ,Lipasin ,Refeeding-induced fat and liver protein ,ANGPTL8 ,C19orf80, RIFL ,UNQ599/PRO1185 ,
Tissue Specificity: Predominantly expressed in liver. Also expressed in adipose tissues. .
Background: ANGPTL8 (also known as lipasin, originally Betatrophin) is a protein that in humans is encoded by the C19orf80 gene. The gene for betatrophin lies on mouse chromosome 9 (gene symbol: Gm6484) and on human chromosome 19 (gene symbol: C19orf80). The encoded 22 kDa protein contains an N-terminal secretion signal and two coiled-coil domains and is a member of the angiopoietin-like (ANGPTL) protein family. However, in contrast to other ANGPTL proteins, betatrophin lacks the C-terminal fibrinogen-like domain, and therefore it is an atypical member of the ANGPTL family. It shares with Angptl4 and Angptl3 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression causes elevation of circulating Triglyceride levels in mice. In mice betatrophin is secreted by the liver. It was hoped that betatrophin or its homolog in humans may provide an effective treatment for type 2 diabetes and perhaps even type I diabetes.
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分子量
- 22 kDa
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基因ID
- 55908
抗原
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