C19ORF80 抗体
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北京 101111
Quick Overview for C19ORF80 抗体 (ABIN5564288)
抗原
See all C19ORF80 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- anti-Betatrophin (human), pAb (IN108)
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特异性
- Recognizes human betatrophin.
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产品特性
- Polyclonal Antibody. Recognizes human ANGPTL8 [Betatrophin]. Source: Rabbit. Applications: ELISA, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. ANGPTL8 (Angiopoietin-like protein 8, RIFL, Lipasin, Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
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免疫原
- Recombinant human ANGPTL8 (betatrophin).
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anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 16-198) antibody
C19ORF80 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibodyC19ORF80 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 24-196) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Monoclonal D3 unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 22-198) antibodyC19ORF80 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 1-251) antibodyC19ORF80 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).
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- C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))
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别名
- Betatrophin
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背景
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Alternate Names/Synonyms: Angiopoietin-like Protein 8, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL, Betatrophin
Product Description: ANGPTL8 (Angiopoietin-like protein 8, RIFL, Lipasin, Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
抗原
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