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JAK1 抗体 (N-Term)

Name: JAK1 抗体 (N-Term)
SKU: ABIN5518768
Availability: OutOfStock

JAK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Western blot analysis of JAK1 expression in rat kidney extract ( Lane 1), mouse kidney extract ( Lane 2) and HELA whole cell lysates ( Lane 3). (JAK1 抗体 (N-Term))

1 image

(1 reference)

产品编号 ABIN5518768

发货至: 中国

Datasheet as PDF

抗原 See all JAK1 抗体

JAK1 (Janus Kinase 1 (JAK1))
抗原表位
16

16

8

5

5

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 78-115, N-Term
适用
94

71

51

2

2

2

2
人, 小鼠, 大鼠
宿主
70

25

1

1
兔
Compatible Secondaries
克隆类型
67

30
多克隆
标记
49

4

4

3

3

3

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1

1
This JAK1 antibody is un-conjugated
应用范围
68

29

23

14

14

13

11

8

8

4

3

2

1

1
Western Blotting (WB)

原理

Anti-JAK1 Antibody Picoband®

序列

FALYDENTKL WYAPNRTITV DDKMSLRLHY RMRFYFTN

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-JAK1 Antibody Picoband® (ABIN5518768). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human JAK1, different from the related mouse sequence by three amino acids.

亚型

IgG

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anti-Janus Kinase 1 (JAK1) (pTyr1022) antibody
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JAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

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JAK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB43812 unconjugated

anti-Janus Kinase 1 (JAK1) (AA 172-204), (N-Term) antibody
JAK1 适用: 人 WB 宿主: 兔 Polyclonal RB43809 unconjugated

anti-Janus Kinase 1 (JAK1) antibody
JAK1 适用: 人, 大鼠 WB, IP 宿主: 小鼠 Monoclonal 7B1-B6-G7 unconjugated

anti-Janus Kinase 1 (JAK1) (Ser639) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (C-Term) antibody
JAK1 适用: 人, 小鼠, 大鼠, 小鸡, 犬, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (pTyr1034), (pTyr1035) antibody
JAK1 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001). "Signaling by type I and II cytokine receptors: ten years after". 2. Gough, N. M., Rakar, S., Harpur, A., Wilks, A. F. Localization of genes for two members of the JAK family of protein tyrosine kinases to murine chromosomes 4 and 19. Mammalian Genome 6: 247-248, 1995. 3. Howard, O. M. Z., Dean, M., Young, H., Ramsburg, M., Turpin, J. A., Michiel, D. F., Kelvin, D. J., Lee, L., Farrar, W. L. Characterization of a class 3 tyrosine kinase. Oncogene 7: 895-900, 1992.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
抗原

JAK1 (Janus Kinase 1 (JAK1))

别名

JAK1 (JAK1 产品)

背景

Synonyms: Tyrosine-protein kinase JAK1,2.7.10.2,Janus kinase 1,JAK-1,JAK1,JAK1A, JAK1B,
Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. .
Background: JAK1 (JANUS KINASE 1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It is a member of a new class of PTKs that are a large family of proteins characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain--hence the name Janus. The JAK1 gene is mapped to 1p31.3. JAK1 is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Additionally, Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

分子量

133 kDa

基因ID

3716

UniProt

P23458

途径

JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response