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EPAS1 抗体 (Middle Region)

Name: EPAS1 抗体 (Middle Region)
SKU: ABIN5518650
Availability: OutOfStock

EPAS1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Western blot analysis of HIF2A using anti- HIF2A antibody .

1 image

(1 reference)

产品编号 ABIN5518650

发货至: 中国

Datasheet as PDF

抗原 See all EPAS1 抗体

EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
抗原表位
16

11

9

7

7

6

6

6

6

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 282-301, Middle Region
适用
91

48

42

18

17

3

3

2

2

2

2

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
99

11

1

1
兔
Compatible Secondaries
克隆类型
91

21
多克隆
标记
56

14

7

5

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1
This EPAS1 antibody is un-conjugated
应用范围
91

47

32

23

15

14

14

13

13

11

5

4

4

2

1

1

1

1
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for Endothelial PAS domain-containing protein 1(EPAS1) detection. Tested with WB in Human,Mouse,Rat.

序列

HALDSENMTK SHQNLCTKGQ

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Endothelial PAS domain-containing protein 1(EPAS1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: endothelial PAS domain protein 1
Protein Name: Endothelial PAS domain-containing protein 1(EPAS-1)

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence in the middle region of human HIF-2-alpha(282-301aa, HALDSENMTKSHQNLCTKGQ), identical to the related mouse and rat sequence.

亚型

IgG

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anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 21-336) antibody
EPAS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (Ser343) antibody
EPAS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 680-870) antibody
EPAS1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1H3E12 unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (C-Term) antibody
EPAS1 适用: 人, 小鼠, 大鼠, 鱼, 灵长类 WB, ELISA, IP, FACS, ICC, IHC (p), IF, IHC (fro), ChIP, GS 宿主: 兔 Polyclonal unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 28-347) antibody
EPAS1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G2 unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) antibody
EPAS1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 535-631) antibody
EPAS1 适用: 人, 小鼠, 大鼠, Hamster WB, ELISA, IHC, IP, FACS, ICC, IF, ChIP 宿主: 小鼠 Monoclonal ep190b unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 1-130) antibody
EPAS1 适用: 人, 小鼠, 大鼠, 猴, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 26-347) antibody
EPAS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Sodium azide, Thimerosal (Merthiolate)

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Lu, Shi, Ma, Wang, Liu, Chuai, Song, Münsterberg, Cao, Yang: "Proper autophagy is indispensable for angiogenesis during chick embryo development." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 13, pp. 1742-54, (2017) (PubMed).
抗原

EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

别名

EPAS1 (EPAS1 产品)

别名

EPAS1 antibody, ECYT4 antibody, HIF2A antibody, HLF antibody, MOP2 antibody, PASD2 antibody, bHLHe73 antibody, HIF-2alpha antibody, HRF antibody, Hif2a antibody, bhlhe73 antibody, ecyt4 antibody, hif2 antibody, hif2a antibody, hif2alpha antibody, hlf antibody, mop2 antibody, pasd2 antibody, EPAS antibody, EPAS-1 antibody, endothelial PAS domain protein 1 antibody, endothelial PAS domain protein 1 L homeolog antibody, EPAS1 antibody, epas1 antibody, Epas1 antibody, epas1.L antibody

背景

HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88 % identical to human EPAS1. The human EPAS1 gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding the N-terminal bHLH-PAS domains of EPAS1 and AHR are similar, suggesting that the 5-prime ends of the 2 genes may have arisen from a gene duplication event1. Moreover, the predicted protein shares 48 % sequence identity with HIF1-alpha, a bHLH-PAS transcription factor that induces EPO gene expression in cultured cells in response to hypoxia. Like HIF1A, EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene. EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo. Furthermore, EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia2. HIF2A is expressed at relatively higher levels in villus sections of placenta and in lung samples compared with other tissues examined3. In addition, The variation in EPAS1 influences the relative contribution of aerobic and anaerobic metabolism and hence the maximum sustainable metabolic power for a given event duration4.

Synonyms: Basic helix loop helix PAS protein MOP2 antibody|Basic-helix-loop-helix-PAS protein MOP2 antibody|bHLHe73 antibody|Class E basic helix-loop-helix protein 73 antibody|ECYT4 antibody|Endothelial PAS domain containing protein 1 antibody|Endothelial pas domain protein 1 antibody|Endothelial PAS domain-containing protein 1 antibody|EPAS 1 antibody|EPAS-1 antibody|EPAS1 antibody|EPAS1_HUMAN antibody|HIF 1 alpha like factor antibody|HIF 2 alpha antibody|HIF-1-alpha-like factor antibody|HIF-2-alpha antibody|HIF2-alpha antibody|Hif2a antibody|HLF antibody|Hypoxia inducible factor 2 alpha antibody|Hypoxia inducible factor 2 alpha subunit antibody|Hypoxia-inducible factor 2-alpha antibody|Member of PAS protein 2 antibody|Member of pas superfamily 2 antibody|MOP 2 antibody|MOP2 antibody|PAS domain-containing protein 2 antibody|PASD2 antibody

UniProt

Q99814

途径

Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect