Nibrin 抗体 (AA 350-400)
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Quick Overview for Nibrin 抗体 (AA 350-400) (ABIN504727)
抗原
See all Nibrin (NBN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 350-400
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交叉反应
- 人, 小鼠
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纯化方法
- affinity purified
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免疫原
- Synthetic peptide made to an internal portion of the mouse protein (within AA 350-400). [Swiss-Prot# Q9R207].
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -20 °C
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- Nibrin (NBN)
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别名
- p95/NBS1
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背景
- The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
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UniProt
- Q9R207
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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