TIA1 抗体 (AA 182-385)
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Quick Overview for TIA1 抗体 (AA 182-385) (ABIN5027559)
抗原
See all TIA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 182-385
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纯化方法
- Protein G Chromatography
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免疫原
- A partial length recombinant TIA-1 protein (amino acids 182-385) was used as the immunogen for this antibody.
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亚型
- IgG1
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应用备注
- WB: 2-4 μg/mL, IHC: 5-10 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
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别名
- TIA-1
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背景
- TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5'splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.
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分子量
- 44 kDa
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基因ID
- 7072
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UniProt
- P31483
抗原
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