PAPPA 抗体 (AA 332-561)
Our Local Distributor
北京 101111
Quick Overview for PAPPA 抗体 (AA 332-561) (ABIN5027424)
抗原
See all PAPPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 332-561
-
纯化方法
- Protein G Chromatography
-
免疫原
- A partial length recombinant PAPP-A protein (amino acids 332-561) was used as the immunogen for this antibody.
-
亚型
- IgG2b kappa
-
-
-
-
应用备注
- IHC: 5-10 μg/mL
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS containing 0.05 % BSA, PH 7.4
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
-
-
- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
-
别名
- PAPP-A
-
背景
- PAPP-A (pregnancy-associated plasma protein A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. It has prognostic impact in pregnancy and acute coronary syndrome. PAPP-A regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD (Adult Growth Hormone Deficiency) patients.
-
基因ID
- 60676
-
UniProt
- Q9BXP8
抗原
-