DLL4 抗体 (AA 423-650)
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北京 101111
Quick Overview for DLL4 抗体 (AA 423-650) (ABIN5027156)
抗原
See all DLL4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 423-650
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant DLL4 protein (amino acids 423-650) was used as the immunogen for this antibody.
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亚型
- IgG
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应用备注
- WB: 2-4 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- DLL4 (delta-Like 4 (DLL4))
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别名
- DLL4
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背景
- Dll4 (Delta-like 4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. It is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. DLL4 signaling is extensively critical for tumor angiogenesis. Blockage of DLL4 signaling inhibits tumor growth by deregulating angiogenesis and promoting non productive angiogenesis. Additionally, DLL4 has been shown to help regulate the cellular actions of VEGF.
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分子量
- 75 kDa
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基因ID
- 54567
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UniProt
- Q9NR61
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途径
- Notch Signaling
抗原
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