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CD73 抗体 (AA 145-346)

This anti-CD73 antibody is a 小鼠 单克隆 antibody detecting CD73 in WB 和 IHC. Suitable for 人.
产品编号 ABIN5027098
发货至: 中国

Quick Overview for CD73 抗体 (AA 145-346) (ABIN5027098)

抗原

See all CD73 (NT5E) 抗体
CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD73 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)

克隆位点

ABM40E2
  • 抗原表位

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    AA 145-346

    纯化方法

    Protein G Chromatography

    免疫原

    A partial length recombinant CD73 protein (amino acids 145-346) was used as the immunogen for this antibody.

    亚型

    IgG2a kappa
  • 应用备注

    WB: 2-4 μg/mL, IHC: 5 μg/mL

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS containing 0.05 % BSA, PH 7.4

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原

    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

    别名

    CD73

    背景

    CD73, also known as ecto-5'-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.

    分子量

    63 kDa

    基因ID

    4907

    UniProt

    P21589

    途径

    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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