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TRIM5 抗体 (Isoform alpha, Middle Region)

This anti-TRIM5 antibody is a 兔 多克隆 antibody detecting TRIM5 in WB, IHC (p) 和 EIA. Suitable for 人.
产品编号 ABIN501052
发货至: 中国

Quick Overview for TRIM5 抗体 (Isoform alpha, Middle Region) (ABIN501052)

抗原

See all TRIM5 抗体
TRIM5 (Tripartite Motif Containing 5 (TRIM5))

适用

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宿主

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克隆类型

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多克隆

标记

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This TRIM5 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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    Isoform alpha, Middle Region

    特异性

    This antibody detects TRIM5 / RNF88 alpha at Center.

    交叉反应 (详细)

    Species reactivity (tested):Human

    纯化方法

    Peptide affinity chromatography

    免疫原

    TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of human TRIM5 alpha.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot: 1 to 2 μg/mL. A band at approximately 55 kDa can be detected. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    TRIM5 (Tripartite Motif Containing 5 (TRIM5))

    别名

    TRIM5 / RNF88

    背景

    TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region . TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission.Synonyms: RING finger protein 88, Tripartite motif-containing protein 5

    基因ID

    85363

    NCBI登录号

    NP_149023

    途径

    Activation of Innate immune Response
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