TICAM1 抗体 (C-Term)
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Quick Overview for TICAM1 抗体 (C-Term) (ABIN501042)
抗原
See all TICAM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects TICAM1 / TRIF.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Ion exchange chromatography
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免疫原
- TRIF antibody was raised against a peptide corresponding to 14 amino acids near the C- terminus of human TRIF.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 2 to 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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别名
- TICAM1 / TRIF
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背景
- TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (6).Synonyms: PRVTIRB, Proline-rich vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TIR domain-containing adapter molecule 1, Toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
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基因ID
- 148022
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NCBI登录号
- NP_891549
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
抗原
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