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SKIL 抗体 (N-Term)

SKIL 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500786
发货至: 中国
  • 抗原 See all SKIL 抗体
    SKIL (SKI-Like Oncogene (SKIL))
    抗原表位
    • 15
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 38
    • 32
    • 15
    • 7
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 48
    • 5
    克隆类型
    • 49
    • 4
    多克隆
    标记
    • 29
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SKIL antibody is un-conjugated
    应用范围
    • 43
    • 17
    • 13
    • 13
    • 9
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects SKIL / SnoN. It will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
    交叉反应 (详细)
    Species reactivity (tested):Human, mouse, rat
    纯化方法
    Peptide affinita chromatography
    免疫原
    SnoN antibody was raised against a 16 amino acid peptide from near the amino terminus of human SnoN.
    亚型
    IgG
    Top Product
    Discover our top product SKIL Primary Antibody
  • 应用备注
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原
    SKIL (SKI-Like Oncogene (SKIL))
    别名
    SKIL / SnoN (SKIL 产品)
    别名
    SNO antibody, SnoA antibody, SnoI antibody, SnoN antibody, Skir antibody, Sno antibody, SKIL antibody, DKFZp459L122 antibody, sno antibody, zgc:193698 antibody, SKI like proto-oncogene antibody, SKI-like proto-oncogene antibody, ski-like protein antibody, SKI-like antibody, SKI-like proto-oncogene b antibody, SKIL antibody, Skil antibody, LOC100010058 antibody, skil antibody, skilb antibody
    背景
    TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN.Synonyms: SNO, Ski-like protein, Ski-related novel protein N, Ski-related oncogene, Ski-related protein, SnoA, Snol
    基因ID
    6498
    NCBI登录号
    NP_005405
    UniProt
    P12757
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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