SARM1 抗体 (C-Term)
(2 references)Quick Overview for SARM1 抗体 (C-Term) (ABIN500660)
抗原
See all SARM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects SARM1 at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Ion exchange chromatography
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免疫原
- SARM antibody was raised against a peptide corresponding to amino acids near the C- terminus of human SARM.
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亚型
- IgG
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anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 340-380) antibody
SARM1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (C-Term) antibodySARM1 适用: 人, 小鼠 WB, IHC (p), IF, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 93-292) antibodySARM1 适用: 人 IHC (p), IP, IHC 宿主: 小鼠 Monoclonal Sarmy-1 unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) antibodySARM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 to 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." in: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).
: "Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons." in: Investigative ophthalmology & visual science, Vol. 54, Issue 4, pp. 2771-80, (2013) (PubMed).
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: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." in: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).
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- SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))
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别名
- SARM1
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背景
- Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2
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基因ID
- 23098
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NCBI登录号
- NP_055892
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UniProt
- Q6SZW1
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途径
- TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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