-
- 抗原 See all SARM1 抗体
- SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SARM1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- SARM1 Rabbit pAb
- 交叉反应
- 人
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human SARM1.
- 亚型
- IgG
- Top Product
- Discover our top product SARM1 Primary Antibody
-
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 340-380) antibody
SARM1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (C-Term) antibodySARM1 适用: 人, 小鼠 WB, IHC (p), IF, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (C-Term) antibodySARM1 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Sterile alpha and TIR Motif Containing 1 (SARM1) (AA 93-292) antibodySARM1 适用: 人 IP, IHC (p) 宿主: 小鼠 Monoclonal Sarmy-1 unconjugated
-
- 应用备注
- WB,1:500 - 1:2000,IP,1:50 - 1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
- 抗原
- SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))
- 别名
- SARM1 (SARM1 产品)
- 别名
- A830091I15Rik antibody, C78606 antibody, MyD885 antibody, Sarm antibody, MyD88-5 antibody, SAMD2 antibody, SARM antibody, sterile alpha and TIR motif containing 1 antibody, sterile alpha and HEAT/Armadillo motif containing 1 antibody, SARM1 antibody, Sarm1 antibody, sarm1 antibody
- 背景
- NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide, NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.,SARM, HsTIR, SAMD2, hSARM1, MyD88-5,SARM1
- 分子量
- 79kDa
- 基因ID
- 23098
- UniProt
- Q6SZW1
- 途径
- TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
-
You are here:
