UIMC1 抗体 (N-Term)
Quick Overview for UIMC1 抗体 (N-Term) (ABIN500569)
抗原
See all UIMC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects UIMC1 / RAP80 at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- RAP80 antibody was raised against a 17 amino acid peptide from near the amino terminus of human RAP80.
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亚型
- IgG
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anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-230) antibody
UIMC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 161-235) antibodyUIMC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (C-Term) antibodyUIMC1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (N-Term) antibodyUIMC1 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-385) antibodyUIMC1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 567-601), (C-Term) antibodyUIMC1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB48354 unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) antibodyUIMC1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (Internal Region) antibodyVerified UIMC1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (AA 1-385) antibodyUIMC1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) (C-Term) antibodyUIMC1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
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别名
- UIMC1 / RAP80
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背景
- RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.Synonyms: BRCA1-A complex subunit RAP80, RXRIP110, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1
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基因ID
- 51720
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UniProt
- Q96RL1
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途径
- DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
抗原
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