PAK2 抗体 (C-Term)
Quick Overview for PAK2 抗体 (C-Term) (ABIN500439)
抗原
See all PAK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects PAK2 at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- 14 amino acid peptide from near the carboxy terminus of human PAK2
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亚型
- IgG
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anti-P21-Activated Kinase 2 (PAK2) (AA 131-230) antibody
PAK2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1E1 unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 1-212) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人 WB, ELISA, IP, FACS 宿主: 兔 Monoclonal 6D12 unconjugated Recombinant Antibody
anti-P21-Activated Kinase 2 (PAK2) (AA 177-419) antibodyPAK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 192-222) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibodyPAK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (pSer20) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (Ser62) antibodyPAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (Ser192) antibodyPAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- PAK2 (P21-Activated Kinase 2 (PAK2))
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别名
- PAK2
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背景
- The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58
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基因ID
- 5062
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NCBI登录号
- NP_002568
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UniProt
- Q13177
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途径
- MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
抗原
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