NDEL1 抗体 (N-Term)
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Quick Overview for NDEL1 抗体 (N-Term) (ABIN500391)
抗原
See all NDEL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects NDEL.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse
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纯化方法
- Peptide affinity chromatpography
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免疫原
- Nudel antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Nudel.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))
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别名
- NDEL
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背景
- Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration (1,2). It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration, phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology (1,3). It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions (4). Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus (3).Synonyms: EOPA, MITAP1, NUDEL, Nuclear distribution protein nudE-like 1
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基因ID
- 81565
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UniProt
- Q9GZM8
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途径
- Regulation of Cell Size
抗原
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