MICA 抗体 (C-Term)
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Quick Overview for MICA 抗体 (C-Term) (ABIN500280)
抗原
See all MICA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects MICA.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse
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纯化方法
- Peptide affinity chromatography
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免疫原
- MICA antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MICA.
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亚型
- IgG
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应用备注
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ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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别名
- MICA
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背景
- Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.Synonyms: MHC class I polypeptide-related sequence A, MIC-A, PERB11.1
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基因ID
- 4276
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NCBI登录号
- NP_000238
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UniProt
- Q29983
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途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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