Endonuclease G 抗体
Quick Overview for Endonuclease G 抗体 (ABIN499796)
抗原
See all Endonuclease G (ENDOG) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human EndoG Peptide
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亚型
- IgG
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anti-Endonuclease G (ENDOG) (AA 101-200) antibody
ENDOG 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 16-290) antibodyENDOG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 55-70) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 49-297) antibodyENDOG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 50-297) antibodyENDOG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (C-Term) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 76-170) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB 宿主: 小鼠 Monoclonal 7G1C10 unconjugated
anti-Endonuclease G (ENDOG) (AA 1-294) antibodyENDOG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 188-217), (C-Term) antibodyENDOG 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB19287 unconjugated
anti-Endonuclease G (ENDOG) (Middle Region) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western 1 to 2 μg/mL. HepG2 and 3T3 cell lysates can be used as positive control and a 35 kDa band can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- Endonuclease G (ENDOG)
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别名
- Endonuclease G
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背景
- The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndooG also cleaves DNA in vitro (4).Synonyms: ENDOG
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基因ID
- 2021
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NCBI登录号
- NP_004426
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UniProt
- Q14249
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途径
- Apoptosis
抗原
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