Claudin 1 抗体 (C-Term)
Quick Overview for Claudin 1 抗体 (C-Term) (ABIN499639)
抗原
See all Claudin 1 (CLDN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody recognizes CLDN1.
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纯化方法
- Peptide Affinity Chromatography
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免疫原
- 20 amino acid peptide near the carboxyl terminus of Human CLDN1
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亚型
- IgG
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anti-Claudin 1 (CLDN1) (AA 1-211) antibody
CLDN1 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 1C5-D9 unconjugated
anti-Claudin 1 (CLDN1) (AA 1-211) antibodyCLDN1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2E2-H5 unconjugated
anti-Claudin 1 (CLDN1) (AA 121-211) antibodyCLDN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 50-197) antibodyCLDN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 1-212) antibodyCLDN1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1C5-D9 unconjugated
anti-Claudin 1 (CLDN1) (C-Term) antibodyCLDN1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 1-211) antibodyCLDN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 185-224) antibodyCLDN1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (Tyr210) antibodyCLDN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 24-161) antibodyCLDN1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: CLDN1 antibody can be used for detection of CLDN1 at 1-2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS, 0.02 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Claudin 1 (CLDN1)
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别名
- Claudin-1 / CLDN1
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背景
- Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.Synonyms: CLD1, PRO944, SEMP1, Senescence-associated epithelial membrane protein, UNQ481
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基因ID
- 9076
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UniProt
- O95832
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途径
- Cell-Cell Junction Organization, Hepatitis C
抗原
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