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CCR3 抗体 (C-Term)

This anti-CCR3 antibody is a 兔 多克隆 antibody detecting CCR3 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN499597
发货至: 中国

Quick Overview for CCR3 抗体 (C-Term) (ABIN499597)

抗原

See all CCR3 抗体
CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This CCR3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

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    C-Term

    特异性

    CCR3 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human CCR3.

    纯化方法

    Immunoaffinity

    免疫原

    Human CCR3 (C-Terminus) Peptide

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: CCR3 antibody can be used for the detection of CCR3 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C.
  • 抗原

    CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

    别名

    CD193 / CCR3

    背景

    Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophil eotaxin receptor

    基因ID

    1232

    NCBI登录号

    NP_847899

    UniProt

    P51677
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