IL-18 抗体 (Internal Region)
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北京 101111
Quick Overview for IL-18 抗体 (Internal Region) (ABIN499167)
抗原
See all IL-18 (IL18) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-NPPDNIKDTK SDI
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特异性
- This antibody detects Interleukin-18.
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交叉反应 （详细）
- Species reactivity (expected):Rabbit, ratSpecies reactivity (tested):Human
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纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from the internal region of the protein sequence according to NP_001553.1.
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anti-Interleukin 18 (IL18) (AA 37-194) antibody
IL18 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 (IL18) (Internal Region) antibodyVerified IL18 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin 18 (IL18) (AA 37-193) antibodyIL18 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C14 unconjugated
anti-Interleukin 18 (IL18) (AA 36-192) antibodyIL18 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 (IL18) (AA 37-193) antibodyIL18 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 (IL18) (AA 32-192) antibody (APC)IL18 适用: 兔 WB, IHC, IP, ICC 宿主: 豚鼠 Polyclonal APC
anti-Interleukin 18 (IL18) (AA 94-193) antibodyIL18 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C10 unconjugated
anti-Interleukin 18 (IL18) (AA 36-192) antibodyIL18 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 18 (IL18) (AA 37-194) antibodyIL18 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Interleukin 18 (IL18) (AA 32-192) antibodyIL18 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D3 unconjugated
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应用备注
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Peptide ELISA: limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 23 kDa band observed in Human Placenta lysates and inlysates of cell line HeLa (calculated MW of 22.3 kDa according to NP_001553.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C up to one week or (in aliquots) at -20 °C for longer.
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: "Aqueous Terminalia arjuna extract modulates expression of key atherosclerosis-related proteins in a hypercholesterolemic rabbit: A proteomic-based study." in: Proteomics. Clinical applications, Vol. 10, Issue 7, pp. 750-9, (2017) (PubMed).
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- IL-18 (IL18) (Interleukin 18 (IL18))
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别名
- Interleukin-18 / IL18
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背景
- IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.Synonyms: IGIF, IL-1 gamma, IL-18, IL1 gamma, IL1F4, Iboctadekin, Interferon-gamma-inducing factor, Interleukin-1 gamma
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基因ID
- 3606
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NCBI登录号
- NP_001553
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UniProt
- Q14116
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途径
- Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
抗原
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