PAK2 抗体
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北京 101111
Quick Overview for PAK2 抗体 (ABIN499019)
抗原
See all PAK2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PAKγ protein. (region surrounding Arg186)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
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纯度
- > 95 % by SDS-PAGE
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anti-P21-Activated Kinase 2 (PAK2) (AA 1-288) antibody
PAK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 131-230) antibodyPAK2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1E1 unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyKD Validated PAK2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2595 unconjugated Recombinant Antibody
anti-P21-Activated Kinase 2 (PAK2) (AA 1-212) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) antibodyPAK2 适用: 人 WB, ELISA, IP, FACS 宿主: 兔 Monoclonal 6D12 unconjugated Recombinant Antibody
anti-P21-Activated Kinase 2 (PAK2) (AA 192-222), (N-Term) antibodyPAK2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1221-1222 unconjugated
anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibodyPAK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 2 (PAK2) (AA 192-222) antibodyPAK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PAK2 (P21-Activated Kinase 2 (PAK2))
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别名
- PAK2
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背景
- Three isoforms of serine/threonine kinases, designated 7PAK p68, 8PAK p65 and 9PAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The 7, 8, and 9 PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on 9 PAK, including Ser 19, Ser 141 Thr 402, phosphorylation of Ser 141 and Thr 402 is correlated with 9 PAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is Mek kinase, an upstream effector of Mek4, which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP dependent manner with Rac 1 and Cdc 42, they do not interact with Rho.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58
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分子量
- approx. 58 kDa
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基因ID
- 5062
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NCBI登录号
- NP_002568
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UniProt
- Q13177
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途径
- MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
抗原
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