Stathmin 1 抗体 (pSer16)
Our Local Distributor
北京 101111
Quick Overview for Stathmin 1 抗体 (pSer16) (ABIN498735)
抗原
See all Stathmin 1 (STMN1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer16
-
特异性
- This antibody detects endogenous levels of Op18 protein only when phosphorylated at Ser16.
-
交叉反应 （详细）
-
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography
-
纯度
- > 95 % by SDS-PAGE
-
-
anti-Stathmin 1 (STMN1) (AA 2-149) antibody
STMN1 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) antibodySTMN1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Stathmin 1 (STMN1) (C-Term) antibodyKO Validated STMN1 适用: 人 WB, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (AA 2-34), (N-Term) antibodySTMN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (C-Term) antibodyVerified STMN1 适用: 人, 小鼠 WB, IHC, ELISA, EIA 宿主: 山羊 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (pSer15) antibodySTMN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (pSer25) antibodySTMN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (pSer38) antibodySTMN1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stathmin 1 (STMN1) (AA 40-149) antibodySTMN1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Stathmin 1 (STMN1) (AA 85-119) antibodySTMN1 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1,0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- Stathmin 1 (STMN1)
-
别名
- Stathmin / STMN1
-
背景
- Oncoprotein 18 (Op18) is a regulator of microtubule (MT) dynamics. Op18 is a target for both cell cycle and cell surface receptor-coupled kinase systems, and phosphorylation of Op18 on specific combinations of amino acid residues has been shown to switch off MT-destabilizing activity of Op18. Induced expression of the catalytic subunit of cAMPdependent protein kinase (PKA) results in a dramatic increase in cellular MT polymer content concomitant with phosphorylation and partial degradation of Op18. Phosphorylation of Op18 on two specific sites, Serine 16 and Serine 63, is necessary and sufficient for PKA to switch off Op18 activity in intact cells. PKA phosphorylation down-regulates the MT-destabilizing activity of Op18, which in turn promotes increased Tubulin polymerization. Op18 has the potential to regulate the MT system in response to external signals such as cAMP-linked agonists.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19
-
分子量
- approx. 19 kDa
-
基因ID
- 3925
-
NCBI登录号
- NP_005554
-
UniProt
- P16949
-
途径
- MAPK Pathway, Microtubule Dynamics
抗原
-
