Caspase 12 抗体
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Quick Overview for Caspase 12 抗体 (ABIN498553)
抗原
See all Caspase 12 (CASP12) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Caspase12 protein. (region surrounding Pro99)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 201-300) antibody
CASP12 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-244) antibodyCASP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-413) antibodyCASP12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB31705 unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 71-84) antibodyCASP12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 100-116) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 61-282) antibodyCASP12 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-100) antibodyCASP12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
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别名
- Caspase-12
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背景
- A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase- 5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.Synonyms: CASP-12, CASP12, Inactive caspase-12
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分子量
- approx. 49 kDa
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基因ID
- 100506742
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NCBI登录号
- NP_001177945
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UniProt
- Q6UXS9
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途径
- Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
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