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BIRC7 抗体

This 兔 多克隆 antibody specifically detects BIRC7 in WB. It exhibits reactivity toward 人.
产品编号 ABIN498547
发货至: 中国
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Quick Overview for BIRC7 抗体 (ABIN498547)

抗原

See all BIRC7 抗体
BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

适用

  • 66
  • 17
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  • 1

宿主

  • 60
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  • 1

克隆类型

  • 61
  • 6
多克隆

标记

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  • 1
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This BIRC7 antibody is un-conjugated

应用范围

  • 53
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Western Blotting (WB)
  • 特异性

    This antibody detects endogenous levels of ML-IAP protein.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography using epitope-specific immunogen

    纯度

    > 95 % (by SDS-PAGE)
  • 应用备注

    Western blot: 1: 500 - 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

    别名

    BIRC7 / LIVIN

    背景

    Inhibitor of apoptosis proteins (IAPs) contain conserved, unique aminoterminal baculovirus IAP repeats (BIRs) and usually a C-terminal RING finger domain. Immunoprecipitation and Western blot analysis indicate that ML-IAP, also known as melanoma inhibitor of apoptosis protein, kidney inhibitor of apoptosis protein (KIAP), livin or BIRC7, binds to caspase-3, -7, and -9, but only inhibits caspase-9. Additionally, ML-IAP physically interacts with SMAC through its BIR domain with a very high affinity and this interaction is very specific. The gene which encodes ML-IAP maps to human chromosome 20q13.3. There is controversy regarding the localization of this protein and its involvement in apoptosis, but it has been suggested that ML-IAP may play a complex role in the regulation of apoptosis.Synonyms: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50

    分子量

    approx. 21 kDa

    基因ID

    79444

    NCBI登录号

    NP_071444

    UniProt

    Q96CA5
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