NCF1 抗体
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北京 101111
Quick Overview for NCF1 抗体 (ABIN498263)
抗原
See all NCF1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of p47-phox protein.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-Neutrophil Cytosol Factor 1 (NCF1) (C-Term) antibody
Verified NCF1 适用: 人, 小鼠, Pig WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (AA 151-250) antibodyNCF1 适用: 人, 小鼠, 马 WB, ELISA, IHC (p), IF (cc), FACS 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (AA 63-232) antibodyNCF1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) antibodyNCF1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (pSer359) antibodyNCF1 适用: 人, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (C-Term) antibodyNCF1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (AA 1-390) antibodyNCF1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (Ser304) antibodyNCF1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) antibodyNCF1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosol Factor 1 (NCF1) (AA 331-380), (pSer359) antibodyNCF1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- NCF1 (Neutrophil Cytosol Factor 1 (NCF1))
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别名
- NCF1
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背景
- The heredity disease chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 doamin of p67-phox has been shown to interact with the proline rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.Synonyms: 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-1, NCF-47K, NOXO2, Neutrophil NADPH oxidase factor 1, Neutrophil cytosol factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, SH3PXD1A, p47-phox
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分子量
- approx. 44 kDa
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基因ID
- 653361
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NCBI登录号
- NP_000256
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UniProt
- P14598
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途径
- PI3K-Akt Signaling
抗原
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