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- 抗原 See all RASGRF1 抗体
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RASGRF1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of Ras-GRF1 protein.
- 交叉反应 （详细）
- Species reactivity (tested):Mouse and Rat.
- 纯化方法
- Affinity chromatography using epitope-specific immunogen
- 纯度
- > 95 % (by SDS-PAGE)
- Top Product
- Discover our top product RASGRF1 Primary Antibody
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anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (Ser929) antibody
RASGRF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (Middle Region) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 1-190) antibodyRASGRF1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (pSer916) antibodyRASGRF1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (N-Term) antibodyRASGRF1 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 107-156) antibodyRASGRF1 适用: 人, 小鼠, Cow, 犬, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 467-516) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 猴, Pig, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 1-190) antibodyRASGRF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 907-936) antibodyRASGRF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14017 unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (N-Term) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
- 别名
- RASGRF1 (RASGRF1 产品)
- 别名
- CDC25 antibody, CDC25L antibody, GNRP antibody, GRF1 antibody, GRF55 antibody, H-GRF55 antibody, PP13187 antibody, ras-GRF1 antibody, AI844718 antibody, CDC25Mm antibody, Grf1 antibody, Grfbeta antibody, P190-A antibody, Ras-GRF1 antibody, p190 antibody, p190RhoGEF antibody, cdc25 antibody, rasgrf1 antibody, Ras protein specific guanine nucleotide releasing factor 1 antibody, RAS protein-specific guanine nucleotide-releasing factor 1 antibody, Ras protein specific guanine nucleotide releasing factor 1 S homeolog antibody, si:ch211-234p18.3 antibody, RASGRF1 antibody, Rasgrf1 antibody, rasgrf1.S antibody, si:ch211-234p18.3 antibody, rasgrf1 antibody
- 背景
- A critical step in signal transduction responses to stimulation of cell surface receptors by their ligands involves the accumulation of Ras proteins in their active GTP-bound state. To reach their active GTP-bound state, Ras proteins must first release bound GDP, a rate limiting step mediated by a guanine nucleotide releasing factor (GRF). The mammalian Ras p21 GRF protein has been designated Ras-GRF1 p140. Ras-GRF1 accelerates release of GDP from H- and N-Ras p21 protein in vitro, but not from the related Ral A or Cdc42Hs GTP-binding proteins. Of interest, a region mapping within the amino terminal domain of Ras-GRF1 is similar to both the human breakpoint cluster protein, Bcr, and the Dbl proto-oncogene product, a guanine nucleotide-releasing factor for Cdc42Hs. Ras-GRF2 p135 has also been identified. Ras-GRF2 p135 is highly homologous to Ras-GRF1 p140 except in the region between the REM and CDC25 domains and appears to function similarly to Ras-GRF1 p140.Synonyms: CDC25, GNRP, GRF1, Guanine nucleotide-releasing protein, Ras-GRF1, Ras-specific guanine nucleotide-releasing factor 1, Ras-specific nucleotide exchange factor CDC25
- 基因ID
- 19417
- NCBI登录号
- NP_035375
- UniProt
- P27671
- 途径
- RTK signaling, Cell Division Cycle, M Phase
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