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- 抗原 See all RASGRF1 抗体
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
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抗原表位
- pSer916
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RASGRF1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- 免疫原
- Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1.
- 亚型
- IgG
- Top Product
- Discover our top product RASGRF1 Primary Antibody
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anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (Ser929) antibody
RASGRF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (Middle Region) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 1-190) antibodyRASGRF1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (N-Term) antibodyRASGRF1 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 107-156) antibodyRASGRF1 适用: 人, 小鼠, Cow, 犬, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 467-516) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 猴, Pig, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 1-190) antibodyRASGRF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (AA 907-936) antibodyRASGRF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14017 unconjugated
anti-Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) (N-Term) antibodyRASGRF1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IHC:1:50-1:100,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
- 别名
- RASGRF1 (RASGRF1 产品)
- 别名
- CDC25 antibody, CDC25L antibody, GNRP antibody, GRF1 antibody, GRF55 antibody, H-GRF55 antibody, PP13187 antibody, ras-GRF1 antibody, AI844718 antibody, CDC25Mm antibody, Grf1 antibody, Grfbeta antibody, P190-A antibody, Ras-GRF1 antibody, p190 antibody, p190RhoGEF antibody, cdc25 antibody, rasgrf1 antibody, Ras protein specific guanine nucleotide releasing factor 1 antibody, RAS protein-specific guanine nucleotide-releasing factor 1 antibody, Ras protein specific guanine nucleotide releasing factor 1 S homeolog antibody, si:ch211-234p18.3 antibody, RASGRF1 antibody, Rasgrf1 antibody, rasgrf1.S antibody, si:ch211-234p18.3 antibody, rasgrf1 antibody
- 背景
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Background:
Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx . Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity. Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity. Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity.
Huibin Yang, J. Biol. Chem., Apr 2003, 278: 13278 - 13285.
Huibin Yang, Mol. Biol. Cell, May 2006, 17: 2177 - 2189.
Raymond R. Mattingly, J. Biol. Chem., Dec 1999, 274: 37379.
Tie-Nian Zhu, J. Biol. Chem., May 2007, 282: 14816 - 14826.Aliases: CDC25 antibody, CDC25L antibody, GNRP antibody, GRF1 antibody, GRF55 antibody, Guanine nucleotide exchange factor antibody, Guanine nucleotide releasing factor 55 kD antibody, Guanine nucleotide releasing protein antibody, guanine nucleotide-releasing factor 1 antibody, Guanine nucleotide-releasing protein antibody, H GRF55 antibody, HGRF55 antibody, PP13187 antibody, Ras protein specific guanine nucleotide releasing factor 1 antibody, Ras specific guanine nucleotide releasing factor antibody, Ras specific guanine nucleotide releasing factor CDC25 homolog antibody, Ras specific nucleotide exchange factor CDC25 antibody, Ras-GRF1 antibody, Ras-specific guanine nucleotide-releasing factor 1 antibody, Ras-specific nucleotide exchange factor CDC25 antibody, RASGRF1 antibody, RGRF1_HUMAN antibody
- UniProt
- Q13972
- 途径
- RTK signaling, Cell Division Cycle, M Phase
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