IGF2R 抗体
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Quick Overview for IGF2R 抗体 (ABIN498204)
抗原
See all IGF2R 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of IGF-2R protein. (region surrounding Phe2480)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 424-529) antibody
IGF2R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibodyIGF2R 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibodyIGF2R 适用: 人, Non-Human Primate WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-238 unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibodyIGF2R 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2327-2491) antibodyIGF2R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 160-311) antibodyIGF2R 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F1G1 unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (APC)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 APC
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (FITC)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 FITC
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (PE)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 PE
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2441-2490) antibodyIGF2R 适用: 人, 小鼠, 大鼠 IHC, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
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别名
- CD222 / IGF2R
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背景
- The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is an ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGFβ1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.Synonyms: 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, CI-MPR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, Late Endosome Marker, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, Mannose 6 Phosphate Receptor (Cation independent)
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分子量
- approx. 274 kDa
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基因ID
- 3482
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NCBI登录号
- NP_000867
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UniProt
- P11717
抗原
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