IGF2R 抗体
(2 references)-
- 抗原 See all IGF2R 抗体
- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
-
适用
- 人, Non-Human Primate
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This IGF2R antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
- 特异性
- The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
- 交叉反应 （详细）
- Human, Non-Human Primates
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Recombinant Vaccinia virus encoding CD222.
- 克隆位点
- MEM-238
- 亚型
- IgG1
-
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody
IGF2R 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 424-529) antibodyIGF2R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2327-2491) antibodyIGF2R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 160-311) antibodyIGF2R 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 4F1G1 unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (FITC)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 FITC
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (APC)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 APC
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) antibody (PE)IGF2R 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-238 PE
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2475-2491), (C-Term) antibodyIGF2R 适用: 人, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2201-2400) antibodyIGF2R 适用: 人 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) (AA 2167-2442) antibodyIGF2R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Flow cytometry: Extracellular and intracellular staining. Recommended dilution: 2-6 μg/mL.
Western blotting: Non-reducing conditions. - 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
-
-
: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).
: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).
-
: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).
-
- 抗原
- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
- 别名
- CD222 (IGF2R 产品)
- 别名
- CD222 antibody, CIMPR antibody, M6P-R antibody, MPR1 antibody, MPRI antibody, AI661837 antibody, CI-MPR antibody, M6P/IGF2R antibody, Mpr300 antibody, mpri antibody, cd222 antibody, cimpr antibody, m6p-r antibody, insulin like growth factor 2 receptor antibody, insulin-like growth factor 2 receptor antibody, IGF2R antibody, Igf2r antibody, igf2r antibody
- 背景
- Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
- 基因ID
- 3482
- UniProt
- P11717
-
