CASR 抗体
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北京 101111
Quick Overview for CASR 抗体 (ABIN498191)
抗原
See all CASR 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of CaR protein.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse and Rat.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Calcium-Sensing Receptor (CASR) (AA 874-1088) antibody
CASR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (pThr888) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 121-220) antibodyCASR 适用: Pig WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (C-Term) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) antibodyCASR 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 926-1078) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 216-229), (Extracellular) antibodyCASR 适用: 人 WB, IHC, IF, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 260-287) antibodyCASR 适用: 小鼠 WB 宿主: 兔 Polyclonal RB41198 unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 1-100) antibody (Atto 390)CASR 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 390
anti-Calcium-Sensing Receptor (CASR) (AA 1-100) antibodyCASR 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CASR (Calcium-Sensing Receptor (CASR))
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别名
- CaSR
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背景
- The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CaSR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).Synonyms: Extracellular calcium-sensing receptor, GPRC2A, PCAR1, Parathyroid Cell calcium-sensing receptor
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分子量
- approx. 140 kDa
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基因ID
- 846
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NCBI登录号
- NP_000379
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UniProt
- P41180
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途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
抗原
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