PLCB3 抗体
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北京 101111
Quick Overview for PLCB3 抗体 (ABIN498179)
抗原
See all PLCB3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PLC β3 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 318-468) antibody
PLCB3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyPLCB3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 1050-1150) antibodyPLCB3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyKD Validated PLCB3 适用: 人 WB, ICC 宿主: 兔 Monoclonal 24GB1260 unconjugated Recombinant Antibody
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer537) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 318-468) antibodyPLCB3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) antibodyPLCB3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (AA 16-50) antibodyPLCB3 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB56188 unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (pSer1105) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3) (Thr236) antibodyPLCB3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific) (PLCB3))
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别名
- PLCB3
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背景
- Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2) with molecular weights ranging from 85 to 150 kDa. The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the α subunits of the Gq class of heterotrimeric G proteins and by certain βγ G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are as yet not resolved.Synonyms: 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-3, PLC-beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3
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分子量
- approx. 150 kDa
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基因ID
- 5331
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NCBI登录号
- NP_000923
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UniProt
- Q01970
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途径
- WNT signaling, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, CXCR4-mediated Signaling Events, G-protein mediated Events
抗原
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