SYK 抗体 (AA 195-223)
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Quick Overview for SYK 抗体 (AA 195-223) (ABIN3032716)
抗原
See all SYK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 195-223
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交叉反应 (详细)
- Expected species reactivity: Chicken, Rat
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 195-223 from the mouse protein was used as the immunogen for this Syk antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Syk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Syk antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SYK (Spleen tyrosine Kinase (SYK))
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别名
- Syk
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背景
- Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Phosphorylates USP25 and regulates its intracellular levels (By similarity).
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UniProt
- P48025
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途径
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
抗原
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