PTBP1 抗体 (AA 26-55)
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Quick Overview for PTBP1 抗体 (AA 26-55) (ABIN3032275)
抗原
See all PTBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-55
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交叉反应 (详细)
- Expected species reactivity: Bovine
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 26-55 from the human protein was used as the immunogen for this PTBP1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the PTBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the PTBP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))
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别名
- PTBP1
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背景
- This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
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UniProt
- P26599
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途径
- Regulation of Muscle Cell Differentiation
抗原
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