PSMA 抗体 (AA 161-190)
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北京 101111
Quick Overview for PSMA 抗体 (AA 161-190) (ABIN3030978)
抗原
See all PSMA (FOLH1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-190
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交叉反应 (详细)
- Expected species reactivity: Mouse, Rat, Pig
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 161-190 from the human protein was used as the immunogen for this PSMA antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the PSMA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the PSMA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
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别名
- PSMA
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背景
- GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA). Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All of which refer to the same protein, glutamate carboxypeptidase II. PSMA is strongly expressed in the human prostate, being a hundredfold greater than the expression in most other tissues. In cancer, it is upregulated in expression and has been called the second-most-upregulated gene in prostate cancer, with increase of 8- to 12-fold over the noncancerous prostate. In human prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse. [Wiki]
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UniProt
- Q04609
抗原
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