SMAD2 抗体 (pSer118)
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Quick Overview for SMAD2 抗体 (pSer118) (ABIN3032618)
抗原
See all SMAD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer118
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交叉反应 （详细）
- Expected species reactivity: Bovine, Chicken, Drosophila, Mouse, Pig, Rat, Zebrafish
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-SMAD2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS118 of human SMAD2.
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亚型
- Ig Fraction
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anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) antibody
SMAD2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3G9 unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) antibodySMAD2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (C-Term) antibodySMAD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pSer423), (pSer425), (pSer465), (pSer467) antibodySMAD2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) antibodySMAD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pSer467) antibodySMAD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) antibodySMAD2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D10 unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (N-Term) antibodySMAD2 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pThr183), (pThr221) antibodySMAD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pSer250) antibodyKD Validated SMAD2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4150 unconjugated Recombinant Antibody
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应用备注
- Titration of the phospho-SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:10-1:50,Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-SMAD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
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别名
- Smad2
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背景
- The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
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UniProt
- Q15796
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途径
- Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
抗原
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