ErbB2/Her2 抗体 (pTyr1140)
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Quick Overview for ErbB2/Her2 抗体 (pTyr1140) (ABIN3029502)
抗原
See all ErbB2/Her2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr1140
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原理
- HER2 Antibody / ErbB2 (pY1140)
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1140 of mouse HER2/ERBB2.
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亚型
- Ig Fraction
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anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-372) antibody
ErbB2/Her2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibodyErbB2/Her2 适用: 人, 小鼠, 大鼠, 犬, 猴, 马, Pig, Cow, 兔, Hamster, Avian, Cat, 小鸡, 驴, 山羊, 豚鼠, 绵羊 WB, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibodyErbB2/Her2 适用: 人 IF, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 3B1 unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibodyErbB2/Her2 适用: 人 IHC, IF, FACS 宿主: 小鼠 Monoclonal ERBB2-2452 unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibodyErbB2/Her2 适用: 人 IHC 宿主: 小鼠 Monoclonal ERBB2-3078 unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 1205-1255) antibodyErbB2/Her2 适用: 人, 小鼠 WB, IHC, FACS, IP, ICC 宿主: 兔 Monoclonal BLR241L unconjugated Recombinant Antibody
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (N-Term) antibodyErbB2/Her2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (Extracellular Domain) antibodyErbB2/Her2 适用: 人 IF, ELISA, FACS 宿主: 小鼠 Monoclonal HRB2-282 unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibodyErbB2/Her2 适用: 人 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1196) antibodyErbB2/Her2 适用: 人 WB, IF, DB 宿主: 兔 Polyclonal RB40085 unconjugated
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应用备注
- Titration of the Phospho-ErbB2 (pY1140) Antibody / Signaling Marker may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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别名
- Erbb2
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背景
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ErbB2 receptor tyrosine kinase 2 (ERBB2), also known as HER2, is a transmembrane receptor that regulates cell proliferation, survival, and differentiation through activation of intracellular signaling pathways. Phospho-ErbB2 (pY1140) antibody, also referred to as phospho-HER2 antibody and phospho-ERBB2 antibody in the literature, detects phosphorylation at tyrosine 1140, a residue located within the intracellular domain of HER2 that contributes to downstream signaling activity.
Phosphorylation of HER2 occurs at multiple tyrosine residues following receptor activation, forming a coordinated signaling network that governs pathway engagement. Y1140 is positioned within this network and participates in transmission of signals to downstream pathways such as PI3K/AKT and MAPK. While not as extensively characterized as major activation sites, phosphorylation at Y1140 reflects receptor signaling activity and contributes to propagation of intracellular responses following receptor engagement.
HER2 signaling is a major driver of tumor biology, particularly in cancers characterized by ERBB2 amplification such as breast carcinoma. In these settings, phosphorylation at residues including Y1140 is associated with active signaling states that support tumor cell growth and survival. Detection of phosphorylation at this site provides insight into receptor activity within the broader signaling cascade rather than serving as a primary activation marker alone.
Y1140 functions within a phosphorylation cluster that includes nearby residues such as Y1112, Y1139, Y1221, Y1222, and Y1248. Together, these sites regulate the initiation, propagation, and integration of HER2-mediated signaling. Analysis of phosphorylation at Y1140 complements detection of these other residues and supports a more comprehensive understanding of HER2 signaling dynamics.
Phospho-specific detection of ERBB2 at Y1140 enables investigation of receptor signaling beyond primary activation events, supporting studies focused on pathway activity, signal propagation, and cellular response mechanisms in both normal and disease contexts.
For detection of activated HER2 phosphorylation, see our < a href=../tds/p-erbb2-antibody-py1248-f48395>HER2 phospho antibody (pY1248). -
UniProt
- P70424
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
抗原
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