PAK4 抗体 (AA 187-216)
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Quick Overview for PAK4 抗体 (AA 187-216) (ABIN3032118)
抗原
See all PAK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 187-216
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 187-216 from the mouse protein was used as the immunogen for this Pak4 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Pak4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Pak4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PAK4 (P21-Activated Kinase 4 (PAK4))
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别名
- Pak4
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背景
- Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity).
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UniProt
- Q8BTW9
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途径
- RTK signaling
抗原
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