PAK3 抗体 (AA 218-247)
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Quick Overview for PAK3 抗体 (AA 218-247) (ABIN3032142)
抗原
See all PAK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 218-247
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纯化方法
- Purified
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免疫原
- A portion of amino acids 218-247 from the human protein was used as the immunogen for this PAK3 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the PAK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the PAK3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- PAK3
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别名
- PAK3
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背景
- PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30). The protein structure contains 1 CRIB domain.
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UniProt
- O75914
抗原
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