MUSK 抗体
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北京 101111
Quick Overview for MUSK 抗体 (ABIN3031880)
抗原
See all MUSK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified
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免疫原
- This mouse Musk antibody was produced from a mouse immunized with recombinant protein from a mouse Musk.
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亚型
- IgG1 kappa
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anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 517-777) antibody
MUSK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65), (N-Term) antibodyMUSK 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01497 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB14743 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F3 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-209) antibodyMUSK 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 10A4 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 6D1 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 600-860) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 1429CT456-173-44 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (N-Term) antibodyMUSK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the Musk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:25,Western blot: 1?2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Musk antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
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别名
- Musk
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背景
- Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
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UniProt
- Q61006
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途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
抗原
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