MUC1 抗体 (AA 1176-1205)
Quick Overview for MUC1 抗体 (AA 1176-1205) (ABIN3031859)
抗原
See all MUC1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1176-1205
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 1176-1205 from the human protein was used as the immunogen for this MUC-1 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the MUC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the MUC-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- MUC1 (Mucin 1 (MUC1))
-
别名
- MUC-1
-
背景
- This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq].
-
UniProt
- P15941
-
途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
-