LRP6 抗体 (AA 1531-1560)
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Quick Overview for LRP6 抗体 (AA 1531-1560) (ABIN3028807)
抗原
See all LRP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1531-1560
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纯化方法
- Purified
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免疫原
- A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the LRP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the LRP6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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别名
- LRP6
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背景
- LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
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UniProt
- O75581
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途径
- WNT signaling, Tube Formation
抗原
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