Insulin Receptor 抗体 (AA 21-52)
Quick Overview for Insulin Receptor 抗体 (AA 21-52) (ABIN3031335)
抗原
See all Insulin Receptor (INSR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-52
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交叉反应 (详细)
- Expected species reactivity: Mouse, Rat
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纯化方法
- Purified
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免疫原
- A portion of amino acids 21-52 from the human protein was used as the immunogen for this Insulin Receptor antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Insulin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Insulin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Insulin Receptor (INSR)
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别名
- Insulin Receptor
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背景
- INSR binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.
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UniProt
- P06213
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途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
抗原
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