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HSP27 抗体 (AA 56-85)

This anti-HSP27 antibody is a 兔 多克隆 antibody detecting HSP27 in WB, IHC 和 ELISA. Suitable for 人.
产品编号 ABIN3031143
发货至: 中国

Quick Overview for HSP27 抗体 (AA 56-85) (ABIN3031143)

抗原

See all HSP27 (HSPB1) 抗体
HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

适用

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宿主

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克隆类型

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多克隆

标记

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This HSP27 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
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    AA 56-85

    纯化方法

    Antigen affinity purified

    免疫原

    A portion of amino acids 56-85 from the human protein was used as the immunogen for this HSPB1 antibody.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the HSPB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the HSPB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

    别名

    HSPB1

    背景

    In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.

    UniProt

    P04792

    途径

    MAPK Pathway, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling
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